![]() Traditional antibiotic resistance and veterinary drug residues have been annually increasing and causing a serious global public health threat ( CiŽman and Plankar Srovin, 2018). These results reveal that Myr-36PW is a promising antimicrobial agent against bacterial infections. In addition, the designed peptide Myr-36PW could inhibit the bacterial growth of Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa GIM 1.551 to target organs, decrease the inflammatory damage, show an impressive therapeutic effect on mouse pneumonia and peritonitis experiments, and promote abscess reduction and wound healing in infected mice. Moreover, Myr-36PW exhibited effective anti-biofilm activity against Gram-negative bacteria and may kill bacteria by improving the permeability of their membranes. The fatty acid modification provided the as-prepared peptide with good stability and higher antimicrobial activity compared with PMAP-36PW in vitro. Here, a peptide based on our previously studied peptide PMAP-36PW was designed via N-terminal myristoylation and referred to as Myr-36PW. Antimicrobial peptides (AMPs) are novel antimicrobial drugs with the potential to solve these problems. 3Henan Provincial Open Laboratory of Key Disciplines in Environment and Animal Products Safety, Henan University of Science and Technology, Luoyang, Chinaĭrug-resistant bacteria infections and drug residues have been increasing and causing antibiotic resistance and public health threats worldwide.2Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada.1The Key Lab of Veterinary Biological Products, Henan University of Science and Technology, Luoyang, China.Yongqing Liu 1 † Shengnan Li 2 † Tengfei Shen 1 Liangliang Chen 1 Jiangfei Zhou 1 Shuaibing Shi 1 Yang Wang 3 Zhanqin Zhao 1 Chengshui Liao 3 * Chen Wang 1 * ![]()
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